Arizona Cardinals vs San Francisco 49ers: prediction & pick

Arizona Cardinals visit San Francisco 49ers with the model leaning toward San Francisco 49ers. Our projection has SF favored by roughly 7.0 points, a win probability near 71%, and a projected final of ARI 19 – SF 26.

Against the spread

Comparing our projected margin to the posted line of -11.5 for the home team surfaces a gap the model wants to bet. The recommendation is ARI +11.5, an edge of about 4.5 points in our favor.

Total (over/under)

On the total, the model projects around 45.0 combined points versus a market number of 46.5. That points to the Under 46.5, with about 1.5 points of under edge.

The projection

Running the matchup through the model produces a projected final score of ARI 19 – SF 26, built from each team's power rating, home-field advantage, and pace. See how the model works for the full methodology.

Bottom line: the model rates this a Strong play at 77% confidence. As always, shop for the best available number and size the bet to your bankroll — a single game never makes or breaks a season.