Week 1 · Sun, Oct 25 · 8:05 PM ET

Denver Broncos vs Arizona Cardinals: prediction & pick

When Denver Broncos and Arizona Cardinals meet, our simulation gives the edge to Arizona Cardinals. Our projection has ARI favored by roughly 1.0 points, a win probability near 53%, and a projected final of DEN 22 – ARI 23.

Against the spread

Comparing our projected margin to the posted line of 7.5 for the home team surfaces a gap the model wants to bet. The recommendation is ARI +7.5, an edge of about 8.5 points in our favor.

Total (over/under)

On the total, the model projects around 44.5 combined points versus a market number of 43.5. That points to the Over 43.5, with about 1.0 points of over edge.

The projection

Running the matchup through the model produces a projected final score of DEN 22 – ARI 23, built from each team's power rating, home-field advantage, and pace. See how the model works for the full methodology.

Betting involves risk. Lines move — always confirm the current number at your sportsbook before betting. 21+ where legal.

Bottom line: the model rates this a Strong play at 88% confidence. As always, shop for the best available number and size the bet to your bankroll — a single game never makes or breaks a season.