Week 1 · Sun, Nov 29 · 9:25 PM ET

Seattle Seahawks vs San Francisco 49ers: prediction & pick

Seattle Seahawks visit San Francisco 49ers with the model leaning toward San Francisco 49ers. Our projection has SF favored by roughly 6.0 points, a win probability near 69%, and a projected final of SEA 19 – SF 25.

Against the spread

The market opened at 1.5 on the home side, but our projected margin is far enough from that number to flag value. The recommendation is SF +1.5, an edge of about 7.5 points in our favor.

Total (over/under)

Totals-wise, the simulation expects roughly 44.5 points while the book has hung 46.5. That points to the Under 46.5, with about 2.0 points of under edge.

The projection

Running the matchup through the model produces a projected final score of SEA 19 – SF 25, built from each team's power rating, home-field advantage, and pace. See how the model works for the full methodology.

Betting involves risk. Lines move — always confirm the current number at your sportsbook before betting. 21+ where legal.

Bottom line: the model rates this a Strong play at 88% confidence. As always, shop for the best available number and size the bet to your bankroll — a single game never makes or breaks a season.